One‐Handed Helical Tubular Ladder Polymers for Chromatographic Enantioseparation**

Author:

Zheng Wei1,Oki Kosuke1ORCID,Saha Ranajit2ORCID,Hijikata Yuh2ORCID,Yashima Eiji1ORCID,Ikai Tomoyuki13ORCID

Affiliation:

1. Department of Molecular and Macromolecular Chemistry Graduate School of Engineering Nagoya University Chikusa-ku Nagoya 464-8603 Japan

2. Institute for Chemical Reaction Design and Discovery (WPI-ICReDD) Hokkaido University Sapporo 001-0021 Japan

3. Precursory Research for Embryonic Science and Technology (PRESTO) Japan Science and Technology Agency (JST) Kawaguchi Saitama 332-0012 Japan

Abstract

AbstractDefect‐free one‐handed contracted helical tubular ladder polymers with a π‐electron‐rich cylindrical helical cavity were synthesized by alkyne benzannulations of the random‐coil precursor polymers containing 6,6′‐linked‐1,1′‐spirobiindane‐7,7′‐diol‐based chiral monomer units. The resulting tightly‐twisted helical tubular ladder polymers showed remarkably high enantioseparation abilities toward a variety of chiral hydrophobic aromatics with point, axial, and planar chiralities. The random‐coil precursor polymer and analogous rigid‐rod extended helical ribbon‐like ladder polymer with no internal helical cavity exhibited no resolution abilities. The molecular dynamics simulations suggested that the π‐electron‐rich cylindrical helical cavity formed in the tightly‐twisted tubular helical ladder structures is of key importance for producing the highly‐enantioseparation ability, by which chiral aromatics can be enantioselectively encapsulated by specific π‐π and/or hydrophobic interactions.

Funder

Japan Society for the Promotion of Science

Precursory Research for Embryonic Science and Technology

Publisher

Wiley

Subject

General Chemistry,Catalysis

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