Affiliation:
1. Institut für Organische und Biomolekulare Chemie and Wöhler Research Institute for Sustainable Chemistry (WISCh) Georg-August-Universität Tammannstraße 2 37077 Göttingen Germany
Abstract
AbstractTwofold distal C−H functionalization was accomplished by difunctionalization of nonactivated alkenes to provide rapid access to multifunctionalized molecules. The multicomponent ruthenium‐catalyzed remote 1,n‐difunctionalization (n=6,7) of nonactivated alkenes with fluoroalkyl halides and heteroarenes in a modular manner is reported. The meta‐C(sp2)−H/C‐6(sp3)−H distal functionalization featured mild conditions, unique selectivity, and broad substrate scope with a domino process for twofold remote C(sp2)−H/C(sp3)−H activation of the sequential formation of three different carbon‐centered radicals. A plausible mechanism was proposed based on detailed experimental and computational studies.
Funder
European Research Council
Deutsche Forschungsgemeinschaft
Alexander von Humboldt-Stiftung
China Scholarship Council
Subject
General Chemistry,Catalysis
Cited by
3 articles.
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