Affiliation:
1. School of Chemistry, Raymond & Beverly Sackler Faculty of Exact Sciences Tel Aviv University Tel Aviv 6997801 Israel
2. Department of Biotechnology and Life Science Tokyo University of Agriculture and Technology 4-24-16, Naka-cho, Koganei-shi Tokyo 184-8588 Japan
Abstract
AbstractThe growing number of fungal infections caused by pathogens resistant to one or more classes of antifungal drugs emphasizes the threat that these microorganisms pose to animal and human health and global food security. Open questions remain regarding the mechanisms of action of the limited repertoire of antifungal agents, making it challenging to rationally develop more efficacious therapeutics. In recent years, the use of chemical biology approaches has resolved some of these questions and has provided new promising concepts to guide the design of antifungal agents. By focusing on examples from studies carried out in recent years, this minireview describes the key roles that probes based on antifungal agents and their derivatives have played in uncovering details about their activities, in detecting resistance, and in characterizing the interactions between these agents and their targets.
Funder
Institute of Global Innovation Research, Tokyo University of Agriculture and Technology
Japan Society for the Promotion of Science
Israel Science Foundation
Subject
General Chemistry,Catalysis