Affiliation:
1. Institute of Molecular Plus Tianjin Key Laboratory of Molecular Optoelectronic Science School of Pharmaceutical Science and Technology Tianjin University 92 Weijin Road 300072 Tianjin China
2. State Key Laboratory of Natural and Biomimetic Drugs Chemical Biology Center, School of Pharmaceutical Sciences Peking University 38 Xueyuan Road 100191 Beijing China
Abstract
AbstractThe molecular structure‐editing through selective C−C bond cleavage allows for the precise modification of molecular structures and opens up new possibilities in chemical synthesis. By strategically cleaving C−C bonds and editing the molecular structure, more efficient and versatile pathways for the synthesis of complex compounds could be designed, which brings significant implications for drug development and materials science. o‐Aminophenethyl alcohols and amines are the essential key motifs in bioactive and functional material molecules. The traditional synthesis of these compounds usually requires multiple steps which could generate inseparable isomers and induce low efficiencies. By leveraging a molecular editing strategy, we herein reported a selective ring‐opening amination of isochromans and tetrahydroisoquinolines for the efficient synthesis of o‐aminophenethyl alcohols and amines. This innovative chemistry allows for the precise cleavage of C−C bonds under mild transition metal‐free conditions. Notably, further synthetic application demonstrated that our method could provide an efficient approach to essential components of diverse bioactive molecules.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Beijing Nova Program
Cited by
4 articles.
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