Pharmacological Chaperones for GCase that Switch Conformation with pH Enhance Enzyme Levels in Gaucher Animal Models

Author:

Santana Andrés G.1,Robinson Kyle1,Vickers Chelsea2,Deen Matthew C.3,Chen Hong‐Ming1,Zhou Stephen4,Dai Ben4,Fuller Maria5,Boraston Alisdair B.2,Vocadlo David J.3,Clarke Lorne A.4,Withers Stephen G.1ORCID

Affiliation:

1. Dept. of Chemistry University of British Columbia Vancouver BC, V6T 1Z1 Canada

2. Dept. of Biochemistry and Microbiology University of Victoria Victoria BC, V8W 3P6 Canada

3. Dept. of Chemistry and Dept. of Mol. Biology and Biochemistry Simon Fraser University Burnaby BC, V5A 1S6 Canada

4. Dept. of Medical Genetics University of British Columbia Women's Hospital & Health Centre Vancouver BC, V6H 3N1 Canada

5. Genetics and Molecular Pathology SA Pathology at Women's and Children's Hospital N. Adelaide South Australia 5006 Australia

Funder

Canadian Institutes of Health Research

Canadian Glycomics Network

Natural Sciences and Engineering Research Council of Canada

Publisher

Wiley

Subject

General Chemistry,Catalysis

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