Affiliation:
1. Department of Chemistry, State Key Laboratory of Synthetic Chemistry The University of Hong Kong Pokfulam Road Hong Kong SAR P. R. China
2. Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, School of Medicine and Pharmacy Ocean University of China Qingdao 266003 P. R. China
Abstract
AbstractProteins with highly hydrophobic regions or aggregation‐prone sequences are typically difficult targets for chemical synthesis at the current stage, as obtaining such type of peptides via solid‐phase peptide synthesis requires sophisticated operations. Herein, we report N,O‐benzylidene acetal dipeptides (NBDs) as robust and effective building blocks to allow the direct synthesis of difficult peptides and proteins via a kinked backbone strategy. The effectiveness and easy accessibility of NBDs have been well demonstrated in our chemical syntheses of various challenging peptides and proteins, including chemokine, therapeutic hormones, histone, and glycosylated erythropoietin.
Funder
University Grants Committee
Subject
General Chemistry,Catalysis