Selective Terminal Functionalization of Linear Alkanes**

Author:

Bruffaerts Jeffrey1,Kesten Inbar2,Buhnik‐Rosenblau Keren2,Cohen Anthony1,Edri Nurit2,Cormier Morgan1ORCID,Zhang Yuanfei1ORCID,Ho Guo‐Ming1,Massad Itai1,Halfon‐Verner Hila2,Kashi Yechezkel2,Marek Ilan1ORCID

Affiliation:

1. Schulich Faculty of Chemistry and the Resnick Sustainability Center for Catalysis. Technion-Israel Institute of Technology Haifa 32000 Israel

2. Faculty of Biotechnology and Food Engineering. Technion-Israel Institute of Technology Haifa 32000 Israel

Abstract

AbstractA two‐step sequential strategy involving a biocatalytic dehydrogenation/remote hydrofunctionalization, as a unified and versatile approach to selectively convert linear alkanes into a large array of valuable functionalized aliphatic derivatives is reported. The dehydrogenation is carried out by a mutant strain of a bacteria Rhodococcus and the produced alkenes are subsequently engaged in a remote functionalization through a metal‐catalyzed hydrometalation/migration sequence that subsequently react with a large variety of electrophiles. The judicious implementation of this combined biocatalytic and organometallic approach enabled us to develop a high‐yielding protocol to site‐selectively functionalize unreactive primary C−H bonds.

Funder

HORIZON EUROPE European Research Council

Publisher

Wiley

Subject

General Chemistry,Catalysis

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