Macrocyclic FKBP51 Ligands Define a Transient Binding Mode with Enhanced Selectivity-Reference-Cited by-同舟云学术

Macrocyclic FKBP51 Ligands Define a Transient Binding Mode with Enhanced Selectivity

Published:2021-05-07 Issue:24 Volume:60 Page:13257-13263
ISSN:1433-7851
Container-title:Angewandte Chemie International Edition
language:en
Short-container-title:Angew. Chem. Int. Ed.

Author:

Voll Andreas M.¹,Meyners Christian¹,Taubert Martha C.¹,Bajaj Thomas²,Heymann Tim¹,Merz Stephanie¹,Charalampidou Anna¹,Kolos Jürgen¹,Purder Patrick L.¹,Geiger Thomas M.¹,Wessig Pablo³,Gassen Nils C.²,Bracher Andreas⁴,Hausch Felix¹^ORCID

Affiliation:

1. Department Chemistry and Biochemistry Clemens-Schöpf-Institute Technical University Darmstadt Alarich-Weiss Strasse 4 64287 Darmstadt Germany

2. Research Group Neurohomeostasis Department of Psychiatry and Psychotherapy University of Bonn Venusberg Campus 1 53127 Bonn Germany

3. Universität Potsdam Institut für Chemie Karl-Liebknecht-Strasse 24–25 14476 Potsdam Germany

4. Max-Planck-Institute of Biochemistry Am Klopferspitz 18 82152 Martinsried Germany

Funder

Bayerisches Staatsministerium für Wirtschaft, Infrastruktur, Verkehr und Technologie

Bundesministerium für Bildung und Forschung

Deutsche Forschungsgemeinschaft

Hessisches Ministerium für Wissenschaft und Kunst

Publisher

Wiley

Subject

General Chemistry,Catalysis

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.202017352

Reference66 articles.

1. Selective Inhibitors of FKBP51 Employ Conformational Selection of Dynamic Invisible States

2. Selective Inhibitors of FKBP51 Employ Conformational Selection of Dynamic Invisible States

4. The Prospect of FKBP51 as a Drug Target

5. Peptidyl-Proline Isomerases (PPIases): Targets for Natural Products and Natural Product-Inspired Compounds

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