Verifying in vitro‐determined enzyme contributions to cannabidiol clearance for exposure predictions in human through physiologically‐based pharmacokinetic modeling

Author:

Yeung Cindy H. T.1ORCID,Beers Jessica L.2ORCID,Jackson Klarissa D.2,Edginton Andrea N.1

Affiliation:

1. School of Pharmacy University of Waterloo Waterloo Ontario Canada

2. Division of Pharmacotherapy and Experimental Therapeutics UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill Chapel Hill California USA

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Reference52 articles.

1. Phytocannabinoids: a unified critical inventory

2. A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans

3. Center for Drug Evaluation and Research.Clinical Pharmacology and Biopharmaceutics Review(s): Epidiolex.2017. Available from:https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210365Orig1s000ClinPharmR.pdf. [Accessed March 31 2022].

4. A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects

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