Affiliation:
1. Department of Surgical Oncology P.D. Hinduja Hospital and Medical Research Centre Mumbai India
2. Nanavati Max Institute of Cancer Care, Nanavati Max Super Speciality Hospital Mumbai India
3. Department of Interventional Radiology P.D. Hinduja Hospital and Medical Research Centre Mumbai India
Abstract
AbstractBackground and ObjectivesDespite surgical advances, postoperative complications persist, affecting oncologic outcomes and increasing treatment costs. It is important to identify a marker that can predict postoperative complications, which can help prehabilitate patients before surgery. This study evaluated sarcopenia as a predictive marker of postoperative complications in patients undergoing surgery for gastrointestinal (GI) or hepato–pancreatico–biliary (HPB) cancer.MethodsSarcopenia was assessed using the skeletal muscle index at the third lumbar vertebra on abdominal computed tomography. The predictive ability of sarcopenia was evaluated by adjusting for other clinicopathological factors.ResultsOf the 210 patients, 81 (38.57%) were sarcopenic. The overall morbidity and mortality were 33.81% and 2.86%, respectively. Major complications (Clavien–Dindo Grade ≥ III) were observed in 10.95% patients and sarcopenic patients were significantly more likely to develop major complications (p = 1.42 × 10−10). Sarcopenia (p = 6.13 × 10−6; odds ratio = 12.29) independently predicted postoperative complications and prolonged hospital stay (p = 0.01).ConclusionSarcopenia objectively predicted the development of postoperative complications and prolonged hospital stay in patients undergoing surgery for GI or HPB cancer. This may facilitate the prehabilitation of patients planned for surgery to reduce the risk of complications.
Subject
Oncology,General Medicine,Surgery
Cited by
3 articles.
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