Lychee seed polyphenol protects the blood–brain barrier through inhibiting Aβ(25–35)‐induced NLRP3 inflammasome activation via the AMPK / mTOR / ULK1‐mediated autophagy in bEnd .3 cells and APP / PS1 mice

Author:

Xiong Rui12,Zhou Xiao‐Gang12,Tang Yong12,Wu Jian‐Ming12ORCID,Sun Yue‐Shan12,Teng Jin‐Feng12,Pan Rong3,Law Betty Yuen‐Kwan4,Zhao Ya12,Qiu Wen‐Qiao12,Wang Xiu‐Ling5,Liu Sha3,Wang Yi‐Ling12,Yu Lu2,Yu Chong‐Lin3,Mei Qi‐Bing12,Qin Da‐Lian12,Wu An‐Guo12ORCID

Affiliation:

1. School of Pharmacy Southwest Medical University Luzhou China

2. Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica Southwest Medical University Luzhou China

3. Department of Human Anatomy, School of Preclinical Medicine Southwest Medical University Luzhou China

4. State Key Laboratory of Quality Research in Chinese Medicine Macau University of Science and Technology Macau China

5. Department of Pharmacy, Ministry of Education Key Laboratory of Child Development and Disorders/National Clinical Research Center for Child Health and Disorders/China International Science and Technology Cooperation Base of Child Development and Critical Disorders/Chongqing Key Laboratory of Pediatrics Children's Hospital of Chongqing Medical University Chongqing China

Funder

The National Natural Science Foundation of China

Administration of Traditional Chinese Medicine of Sichuan Province, China

Educational Commission of Sichuan Province, China

Health Commission of Sichuan Province, China

Joint project of Luzhou Municipal People's Government and Southwest Medical University, China

Science and Technology Planning Project of Luzhou, Sichuan Province, China

The Science and Technology Planning Project of Sichuan Province, China

Publisher

Wiley

Subject

Pharmacology

Reference72 articles.

1. Characterization of Impaired Cerebrovascular Structure in APP/PS1 Mouse Brains

2. Permeability of an In Vitro Model of Blood Brain Barrier (BBB)

3. Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

4. Effects of amyloid beta peptide on neurovascular cells;Askarova S.;Central Asian Journal of Global Health,2012

5. Tight junctions in neurological diseases;Bednarczyk J.;Acta Neurobiologiae Experimentalis,2011

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