Colorectal cancer: Review of signaling pathways and associated therapeutic strategies-Reference-Cited by-同舟云学术

Colorectal cancer: Review of signaling pathways and associated therapeutic strategies

Published:2023-05-24 Issue:8 Volume:127 Page:1277-1295
ISSN:0022-4790
Container-title:Journal of Surgical Oncology
language:en
Short-container-title:Journal of Surgical Oncology

Author:

Leiphrakpam Premila D.¹²^ORCID,Rajappa Senthil J.³,Krishnan Mridula⁴,Batra Rishi⁵,Murthy Shilpa S.⁶,Are Chandrakanth¹²^ORCID

Affiliation:

1. Graduate Medical Education, College of Medicine University of Nebraska Medical Center Omaha Nebraska USA

2. Department of Surgery, Division of Surgical Oncology, College of Medicine University of Nebraska Medical Center Omaha Nebraska USA

3. Medical Oncology Basavatarakam Indo‐American Cancer Hospital Hyderabad Telangana India

4. Department of Internal Medicine, Division of Oncology & Hematology, College of Medicine University of Nebraska Medical Center Omaha Nebraska USA

5. Department of Surgery, Division of General Surgery, College of Medicine University of Nebraska Medical Center Omaha Nebraska USA

6. Global Cancer Disparities Initiative, Division of Surgical Oncology Memorial Sloan Kettering Cancer Center New York New York USA

Abstract

AbstractTumor profiling and targeted therapy revolutionized the treatment strategies of metastatic colorectal cancer (mCRC) in the last decade. The heterogeneity of CRC tumors plays a critical role in the development of treatment resistance, which underscores the need to understand the molecular mechanism involved in CRC to develop novel targeted therapeutic strategies. This review provides an overview of the signaling pathways driving CRC, the existing targeted agents, their limitations, and future trends.

Publisher

Wiley

Subject

Oncology,General Medicine,Surgery

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jso.27295

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