Toxicity of soil leaching liquor from coking plant in developmental zebrafish embryos/larvae model

Author:

Yang Guangchao1,Liu Jining1ORCID,Yang Qian2,Gu Wen3

Affiliation:

1. Research and Development Center for Watershed Environmental Eco‐Engineering Beijing Normal University Zhuhai China

2. College of Food Science and Engineering/Collaborative Innovation Center for Modern Grain Circulation and Safety/Key Laboratory of Grains and Oils Quality Control and Processing Nanjing University of Finance and Economics Nanjing China

3. Nanjing Institute of Environmental Sciences Ministry of Ecology and Environment Nanjing China

Abstract

AbstractThe coking industry in China is the largest coke supplier in the world. Contaminated soil in industrial areas poses a serious threat to human and ecosystems. Most of the studies investigated the toxicity of soil from coking plant on soil microorganisms, while the toxic effects of soil leaching liquor on aquatics are limited. In this study, the composition of soil leaching liquor from a coking plant in Taiyuan (TY) was analyzed, and the developmental toxicity on zebrafish was evaluated. The results showed that a total of 91 polycyclic aromatic hydrocarbons were detected in the leaching liquor, followed by phenols and benzene series. The leaching liquor induced developmental impairment in zebrafish larvae, including delayed incubation, deficits in locomotor behavior, vascular and cardiac dysplasia, and impaired neurodevelopment. The results of metabolomics analysis showed that TY soil leaching liquor induced significant metabolic profile disturbances in zebrafish embryos/larvae. The developmental toxicity of the leaching liquor metabolic disorders may be associated with the leaching liquor‐induced abnormalities in zebrafish embryonic development. Metabolic pathways were identified by arginine and proline metabolism, phosphotransferase system, starch and sucrose metabolism, steroid biosynthesis, beta‐alanine metabolism, and nucleotide metabolism pathways.

Funder

National Key Research and Development Program of China

Priority Academic Program Development of Jiangsu Higher Education Institutions

Publisher

Wiley

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