Improving visual acuity with nivolumab plus ipilimumab plus two cycles of chemotherapy following a diagnosis of lung adenocarcinoma with choroidal metastasis: A case report and literature review

Author:

Matsuyama Takahiro1ORCID,Oniwa Masashi1,Tsuruzono Kentaro1,Yasuda Shunsuke1,Yone Mikiko1,Tomioka Yuya1,Uchida Akifumi1,Mitsuyama Hideo1,Kubota Shingo1,Suetsugu Takayuki1,Mizuno Keiko1,Inoue Hiromasa1ORCID

Affiliation:

1. Department of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan

Abstract

AbstractA 75‐year‐old woman presented at our hospital with bilateral visual impairment. Ophthalmological examination revealed multiple choroidal tumours. Chest computed tomography revealed a tumour shadow in the right lower lobe and multiple lymph node metastases in the mediastinum and pulmonary hilum. Following a detailed examination, the patient was diagnosed with primary lung adenocarcinoma (cT1cN3M1c Stage IVB) with choroid metastases. The tumour proportion score of programmed death ligand 1 (PD‐L1) was 1% and EGFR exon 20 insertion mutations were also detected. The patient was administered combination chemotherapy with nivolumab and ipilimumab. Primary lung and metastatic tumours, including the choroid, were reduced, and visual disturbances improved completely. Herein, we describe a rare case in which a combination of chemotherapy with nivolumab and ipilimumab significantly reduced vision loss due to choroidal metastasis.

Publisher

Wiley

Subject

Pulmonary and Respiratory Medicine

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