Affiliation:
1. Department of Oral Diagnosis, Piracicaba Dental School State University of Campinas (UNICAMP) Piracicaba Brazil
2. Department of Pathology School of Medical Sciences, State University of Campinas (UNICAMP) Campinas Brazil
3. Biorepository and Molecular Pathology, Huntsman Cancer Institute University of Utah (UU) Salt Lake City Utah USA
Abstract
AbstractIn this systematic review, we aimed to evaluate the clinicopathological profile of sclerosing polycystic adenoma (SPA). PubMed, Scopus, EMBASE, Lilacs, Web of Science, and gray literature were searched to access cases of SPA in salivary glands. One hundred and thirty cases of SPA were found across 61 selected articles. SPA affected mainly the parotid gland of adults with a mean age of 44.6 years old, with a slight preference for females. The lesion was usually presented as a painless firm mass with a long period of evolution. Histologically, they are well‐delimitated lesions composed of acinar and ductal elements with a variety of cytomorphologic features surrounded by a densely collagenized stroma. PI3K was the most common gene mutation related to SPA. SPA is a benign condition that mainly affects the parotid gland of female patients and it is usually treated by surgical resection with a good prognosis.
Funder
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Fundação de Amparo à Pesquisa do Estado de São Paulo