High Efficacy of Pazopanib on an Undifferentiated Spindle-Cell Sarcoma Resistant to First-Line Therapy Is Identified With a Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model

Author:

Igarashi Kentaro123,Kawaguchi Kei12,Murakami Takashi12,Kiyuna Tasuku12,Miyake Kentaro12,Singh Arun S.4,Nelson Scott D.5,Dry Sarah M.5,Li Yunfeng5,Yamamoto Norio3,Hayashi Katsuhiro3,Kimura Hiroaki3,Miwa Shinji3,Tsuchiya Hiroyuki3,Eilber Fritz C.6,Hoffman Robert M.12ORCID

Affiliation:

1. AntiCancer, Inc.; San Diego California

2. Department of Surgery; University of California; San Diego California

3. Department of Orthopedic Surgery; Kanazawa University; Kanazawa Japan

4. Division of Hematology-Oncology; University of California; Los Angeles California

5. Department of Pathology; University of California; Los Angeles California

6. Division of Surgical Oncology; University of California; Los Angeles California

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference33 articles.

1. Docetaxel and gemcitabine combination in 133 advanced soft-tissue sarcomas: A retrospective analysis;Bay;Int J Cancer,2006

2. Models of human metastatic colon cancer in nude mice orthotopically constructed by using histologically intact patient specimens;Fu;Proc Natl Acad Sci USA,1991

3. A metastatic nude-mouse model of human pancreatic cancer constructed orthotopically with histologically intact patient specimens;Fu;Proc Natl Acad Sci USA,1992

4. A metastatic-orthotopic transplant nude-mouse model of human patient breast cancer;Fu;Anticancer Res,1993

5. Human ovarian carcinoma metastatic models constructed in nude mice by orthotopic transplantation of histologically-intact patient specimens;Fu;Anticancer Res,1993

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