Exploring the links between types 2 diabetes and liver‐related complications: A comprehensive review

Author:

Otero Sanchez Lukas12,Chen Yuping3ORCID,Lassailly Guillaume14,Qi Xiaolong3

Affiliation:

1. Department of Gastroenterology, Hepatopancreatology and Digestive Oncology CUB Hôpital Erasme Université Libre de Bruxelles Brussels Belgium

2. Laboratory of Experimental Gastroenterology Université Libre de Bruxelles Brussels Belgium

3. Center of Portal Hypertension Department of Radiology Zhongda Hospital Medical School Southeast University Nanjing China

4. Service des maladies de l'appareil digestif hôpital Huriez CHU de Lille Université de Lille Lille France

Abstract

AbstractIn recent decades, the prevalence of type 2 diabetes has been steadily increasing, presenting a significant global public health challenge. These epidemiological trends can be attributed to significant lifestyle changes in modern societies, characterized by sedentary behavior and the consumption of hypercaloric, highly processed foods, along with the aging of the human population. As a result, it has become crucial for both public healthcare systems and healthcare providers to prioritize the management of diabetes and identify its systemic consequences. Emerging research has shed light on the links and risks between diabetes and liver events. This comprehensive review aims to explore the complex interplay between type 2 diabetes mellitus and liver‐related outcomes, especially hepatocellular carcinoma and cirrhosis, offering insights into effective methods for detecting liver risk in individuals with diabetes. Additionally, the review will assess the various treatments that could hold the potential for positive outcomes in managing both diabetes and metabolic dysfunction‐associated steatotic liver disease and liver fibrosis.

Funder

Fonds De La Recherche Scientifique - FNRS

Fonds Erasme

Publisher

Wiley

Subject

Gastroenterology,Oncology

Reference116 articles.

1. World Health Organization Media Centre.Diabetes.https://www.who.int/news‐room/fact‐sheets/detail/diabetes

2. Emerging Targets in Type 2 Diabetes and Diabetic Complications

3. The Impact of Obesity and Type 2 Diabetes on Chronic Liver Disease

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