Determination of enalapril and enalaprilat in small human serum quantities for pediatric trials by HPLC-tandem mass spectrometry

Author:

Ramusovic Sergej1,Thielking Gabriele1,Läer Stephanie1

Affiliation:

1. Department of Clinical Pharmacy and Pharmacotherapy; Heinrich-Heine-Universität; Düsseldorf; Germany

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference17 articles.

1. Considerations in the rational design and conduct of phase I/II pediatric clinical trials: avoiding the problems and pitfalls;Abdel-Rahman;Clinical Pharmacology and Therapeutics,2007

2. Translational medicine - a paradigm shift in modern drug discovery and development: the role of biomarkers;Day;Advances in Experimental Medicine and Biology,2009

3. Rapid and sensitive liquid chromatography/tandem mass spectrometry method for simultaneous determination of enalapril and its major metabolite enalaprilat, in human plasma: application to a bioequivalence study;Ghosh;Drug Testing and Analysis,2011

4. LC-MS/MS method for the determination of several drugs used in combined cardiovascular therapy in human plasma;Gonzalez;Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences,2010

5. Simultaneous determination of enalapril and enalaprilat in human plasma by liquid chromatography-tandem mass spectrometry;Gu;Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences,2004

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