The effect of local IL-4 delivery or CCL2 blockade on implant fixation and bone structural properties in a mouse model of wear particle induced osteolysis

Author:

Sato Taishi1,Pajarinen Jukka1,Behn Anthony1,Jiang Xinyi1,Lin Tzu-hua1,Loi Florence1,Yao Zhenyu1,Egashira Kensuke2,Yang Fan13,Goodman Stuart B.13

Affiliation:

1. Department of Orthopaedic Surgery; Stanford University; Stanford California

2. Department of Cardiovascular Research, Development, and Translational Medicine; Kyushu University Graduate School of Medicine; Fukuoka Japan

3. Department of Bioengineering; Stanford University; Stanford California

Funder

National Institutes of Health

California Institute for Regenerative Medicine

National Science Foundation CAREER Award Program

Ellenburg Chair in Surgery in Stanford University

3M Nontenured Faculty Grant

Stanford Chem-H Institute

Jane and Aatos Erkko Foundation

Stanford Child Health Research Institute

Publisher

Wiley

Subject

Metals and Alloys,Biomedical Engineering,Biomaterials,Ceramics and Composites

Reference33 articles.

1. The pathology of orthopedic implant failure is mediated by innate immune system cytokines;Landgraeber;Mediators Inflamm,2014

2. Interaction of materials and biology in total joint replacement-Successes, challenges and future directions;Pajarinen;J Mater Chem B Mater Biol Med,2014

3. The role of macrophages in osteolysis of total joint replacement;Ingham;Biomaterials,2005

4. Macrophages-Key cells in the response to wear debris from joint replacements;Nich;J Biomed Mater Res A,2013

5. Novel biological strategies for treatment of wear particle-induced periprosthetic osteolysis of orthopaedic implants for joint replacement;Goodman;J R Soc Interface,2014

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