Comprehensive Pharmacogenomic Study Reveals an Important Role of UGT1A3 in Montelukast Pharmacokinetics

Author:

Hirvensalo Päivi1,Tornio Aleksi1,Neuvonen Mikko1,Tapaninen Tuija1,Paile-Hyvärinen Maria1,Kärjä Vesa2,Männistö Ville T.3,Pihlajamäki Jussi45,Backman Janne T.1,Niemi Mikko1

Affiliation:

1. Department of Clinical Pharmacology; University of Helsinki and Helsinki University Hospital; Helsinki Finland

2. Department of Pathology; Kuopio University Hospital; Kuopio Finland

3. Department of Medicine; University of Eastern Finland; Kuopio Finland

4. Department of Public Health and Clinical Nutrition; University of Eastern Finland; Kuopio Finland

5. Clinical Nutrition and Obesity Center, Kuopio University Hospital; Kuopio Finland

Funder

European Research Council

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference50 articles.

1. Asthma;Fanta;N. Engl. J. Med.,2009

2. Metabolic profiles of montelukast sodium (Singulair), a potent cysteinyl leukotriene1 receptor antagonist, in human plasma and bile;Balani;Drug Metab. Dispos.,1997

3. Gemfibrozil markedly increases the plasma concentrations of montelukast: a previously unrecognized role for CYP2C8 in the metabolism of montelukast;Karonen;Clin. Pharmacol. Ther.,2010

4. Reevaluation of the microsomal metabolism of montelukast: major contribution by CYP2C8 at clinically relevant concentrations;Filppula;Drug Metab. Dispos.,2011

5. Hepatic microsomal metabolism of montelukast, a potent leukotriene D4 receptor antagonist, in humans;Chiba;Drug Metab. Dispos.,1997

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