Nirmatrelvir combined with ritonavir for preventing and treating COVID-19

Author:

Reis Stefanie1,Metzendorf Maria-Inti2,Kuehn Rebecca3,Popp Maria1,Gagyor Ildiko4,Kranke Peter1,Meybohm Patrick1,Skoetz Nicole5,Weibel Stephanie1

Affiliation:

1. Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine; University Hospital Würzburg; Würzburg Germany

2. Cochrane Metabolic and Endocrine Disorders Group; Institute of General Practice, Medical Faculty of the Heinrich-Heine University Düsseldorf; Düsseldorf Germany

3. Department of Clinical Sciences; Liverpool School of Tropical Medicine; Liverpool UK

4. Department of General Practice; University Hospital Würzburg; Würzburg Germany

5. Cochrane Haematology, Department of Internal Medicine, Faculty of Medicine and University Hospital Cologne; Center for Integrated Oncology, University of Cologne; Cologne Germany

Publisher

Wiley

Subject

Pharmacology (medical)

Reference184 articles.

1. An interventional efficacy and safety, Phase 2/3, double-blind, 2-arm study to investigate orally administered PF-07321332/ritonavir compared with placebo in non hospitalized symptomatic adult participants with COVID-19 who are at increased risk of progressing to severe illness clinicaltrialsregister.eu/ctr-search/search?query=eudract_number:2021-002895-38

2. Effect of nirmatrelvir/ritonavir versus placebo on COVID-19-related hospitalizations and other medical visits;Hammond;Open Forum Infectious Diseases,2022

3. Sustained alleviation and resolution of targeted COVID-19 symptoms with nirmatrelvir/ritonavir versus placebo;Hammond;Open Forum Infectious Diseases,2022

4. Oral nirmatrelvir for high-risk, nonhospitalized adults with COVID-19;Hammond;New England Journal of Medicine,2022

5. EPIC-HR: study of oral PF-07321332/ritonavir compared with placebo in nonhospitalized high risk adults with COVID-19 clinicaltrials.gov/ct2/show/NCT04960202

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