Down-titration and discontinuation strategies of tumour necrosis factor-blocking agents for rheumatoid arthritis in patients with low disease activity

Author:

Verhoef Lise M1,van den Bemt Bart JF23,van der Maas Aatke1,Vriezekolk Johanna E1,Hulscher Marlies E4,van den Hoogen Frank HJ15,Jacobs Wilco CH6,van Herwaarden Noortje1,den Broeder Alfons A15

Affiliation:

1. Sint Maartenskliniek; Department of Rheumatology; Hengstdal 3 Nijmegen Gelderland Netherlands 6574 NA

2. Sint Maartenskliniek; Department of Pharmacy; Hengstdal 3 Nijmegen Gelderland Netherlands 6522JV

3. Radboud University Medical Center; Department of Pharmacy; Nijmegen Netherlands

4. Radboud Institute for Health Sciences, Radboud University Medical Center; IQ healthcare; PO Box 9101 117 KWAZO Nijmegen Netherlands 6500 HB

5. Radboud University Medical Center; Department of Rheumatology; Nijmegen Netherlands

6. The Health Scientist; Fraeylemastraat 13 The Hague Netherlands 2532 TX

Publisher

Wiley

Subject

Pharmacology (medical)

Reference118 articles.

1. Clinical evaluation usefulness of standardized protocol strategies of dose reduction in patients with rheumatoid arthritis in clinical remission treated with biologic therapies. The OPTIBIO study [abstract];Bejerano;Arthritis and Rheumatology,2016

2. A multicentre, randomised, controlled, open-label pilot study on the feasibility of discontinuation of adalimumab in established patients with rheumatoid arthritis in stable clinical remission;Chatzidionysiou;RMD Open,2016

3. Multicenter, randomised, controlled, open-label pilot study of the feasibility of discontinuation of adalimumab in rheumatoid arthritis patients is stable clinical remission;Chatzidionysiou;Arthritis and Rheumatism,2012

4. Optimizing therapy in inflammatory arthritis: prediction of relapse after tapering or stopping treatment for rheumatoid arthritis patients achieving clinical and radiological remission;Miedany;Clinical Rheumatology,2016

5. Targeting the lowest efficacious dose for rheumatoid arthritis patients in remission: clinical and structural impact of a step-down strategy trial based on progressive spacing of TNF-blocker injections (STRASS trial);Fautrel;Annals of Rheumatic Disease,2013

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