1. University of Edinburgh; Edinburgh Clinical Trials Unit; OPD Building Level 2 Western General Hospital Edinburgh UK EH4 2XU
2. University of Manchester, Manchester Academic Health Science Centre; Centre for Musculoskeletal Research, Institute of Inflammation and Repair; Stopford Building Oxford Road Manchester UK M13 9PT
3. University of Liverpool; Institute of Ageing and Chronic Disease; Liverpool UK
4. University of Manchester, Manchester Academic Health Science Centre; Biostatistics, Institute of Population Health; Clinical Sciences Building Salford Royal NHS Foundation Trust Hospital Stott Lane, Salford Manchester UK M6 8HD