Pharmacological treatments for Friedreich ataxia

Author:

Kearney Mary1,Orrell Richard W2,Fahey Michael3,Brassington Ruth4,Pandolfo Massimo5

Affiliation:

1. Irish College of General Practitioners; General Practice; Dunlavin County Wicklow Ireland

2. University College London Institute of Neurology; Department of Clinical Neurosciences; Royal Free Campus Rowland Hill Street London UK NW2 3PF

3. Monash University; Department of Paediatrics; Clayton Victoria Australia 3168

4. National Hospital for Neurology and Neurosurgery; MRC Centre for Neuromuscular Diseases; PO Box 114 London UK WC1N 3BG

5. Hopital Erasme, Université Libre de Bruxelles; Neurology Department; Route de Lennik 808 Brussels Belgium 1070

Publisher

Wiley

Subject

Pharmacology (medical)

Reference57 articles.

1. Coenzyme Q10 and vitamin E deficiency in Friedreich's ataxia: predictor of efficacy of vitamin E and coenzyme Q10 therapy;Cooper;European Journal of Neurology,2008

2. Idebenone treatment in Friedreich patients: one-year-long randomized placebo-controlled trial;Mariotti;Neurology,2003

3. NCT00811681 Effect of pioglitazone administered to patients with Friedreich's ataxia: proof of concept (ACTFRIE) clinicaltrials.gov/ct2/show/NCT00811681

4. NCT00905268 A study of efficacy, safety and tolerability of idebenone in the treatment of Friedreich's ataxia (FRDA) patients (MICONOS) clinicaltrials.gov/ct2/show/NCT00905268

5. Santhera Pharmaceuticals Santhera's MICONOS Trial with Catena/Sovrima in Friedreich's Ataxia misses Primary Endpoint http://www.santhera.com/index.php?docid=212&vid=&lang=&newsdate=201005&newsid=1417424&newslang=en

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