Interleukin-6 blocking agents for treating COVID-19: a living systematic review

Author:

Ghosn Lina123,Assi Rouba123,Evrenoglou Theodoros3,Buckley Brian S4,Henschke Nicholas4,Probyn Katrin4,Riveros Carolina23,Davidson Mauricia3,Graña Carolina123,Bonnet Hillary13,Jarde Alexander3,Ávila Camila5,Nejstgaard Camilla Hansen67,Menon Sonia1,Ferrand Gabriel1,Kapp Philipp8,Breuer Claudia89,Schmucker Christine89,Sguassero Yanina4,Nguyen Thu Van1,Devane Declan101112,Meerpohl Joerg J89,Rada Gabriel513,Hróbjartsson Asbjørn67,Grasselli Giacomo14,Tovey David1,Ravaud Philippe123,Chaimani Anna123,Boutron Isabelle123

Affiliation:

1. Cochrane France; Paris France

2. Centre d’Epidémiologie Clinique, AP-HP, Hôpital Hôtel Dieu, F-75004; Paris France

3. Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Center for Research in Epidemiology and StatisticS (CRESS), F-75004; Paris France

4. Cochrane Response; Cochrane; London UK

5. Epistemonikos Foundation; Santiago Chile

6. Centre for Evidence-Based Medicine Odense (CEBMO) and Cochrane Denmark; Department of Clinical Research, University of Southern Denmark; Odense Denmark

7. Open Patient data Explorative Network (OPEN); Odense University Hospital; Odense Denmark

8. Institute for Evidence in Medicine (for Cochrane Germany Foundation); Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg; Freiburg Germany

9. Cochrane Germany; Cochrane Germany Foundation; Freiburg Germany

10. Evidence Synthesis Ireland; Galway Ireland

11. Cochrane Ireland and HRB-Trials Methodology Research Network; Galway Ireland

12. University of Galway; Galway Ireland

13. UC Evidence Center, Cochrane Chile Associated Center; Pontificia Universidad Católica de Chile; Santiago Chile

14. Department of Anesthesia, Intensive Care and Emergency Department of Anesthesia, Intensive Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Pathophysiology and Transplantation, University of Milan; Milan Italy

Publisher

Wiley

Subject

Pharmacology (medical)

Reference163 articles.

1. Trial of tocilizumab for treatment of severe COVID-19: ARCHITECTS (ARCHITECTS) clinicaltrials.gov/ct2/show/NCT04412772

2. Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19: A meta-analysis;WHO REACT Working Group 2021;JAMA,2021

3. Subcutaneous sarilumab for the treatment of hospitalized patients with moderate to severe COVID19 disease: A pragmatic, embedded randomized clinical trial;Branch-Elliman;PLoS One,2022

4. Sarilumab for patients with moderate COVID-19 disease clinicaltrials.gov/ct2/show/NCT04359901

5. Early administration of tocilizumab in hospitalized COVID-19 patients with elevated inflammatory markers; COVIDSTORM-a prospective, randomized, single-centre, open-label study;Broman;Clinical Microbiology and Infection,2022

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