Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis: A network meta-analysis

Author:

Hazlewood Glen S123,Barnabe Cheryl245,Tomlinson George6,Marshall Deborah25,Devoe Daniel JA5,Bombardier Claire789

Affiliation:

1. University of Calgary; Department of Medicine and Department of Community Health Sciences; 3330 Hospital Drive NW Calgary ON Canada T2N 1N1

2. University of Calgary; McCaig Institute for Bone and Joint Health; Calgary AB Canada T2N 4Z6

3. University of Toronto; Institute of Health, Policy, Management and Evaluation; Toronto ON Canada M5T 3M6

4. University of Calgary; Department of Medicine; 3330 Hospital Dr NW Calgary AB Canada T2N 4N1

5. University of Calgary; Department of Community Health Sciences; Calgary AB Canada

6. University of Toronto; Department of Medicine and Institute of Health Policy, Management and Evaluation; Eaton North, 6th Floor, Room 232B 200 Elizabeth Street Toronto ON Canada M5G 2C4

7. University Health Network; Toronto General Research Institute; Toronto ON Canada M6J 3S3

8. University of Toronto; Department of Medicine and Institute of Health Policy, Management, and Evaluation; Toronto ON Canada M5G 2C4

9. Mount Sinai Hospital; Division of Rheumatology; Toronto ON Canada M5T 3L9

Publisher

Wiley

Subject

Pharmacology (medical)

Reference269 articles.

1. A multicenter, double-blind, randomized, placebo controlled trial of infliximab combined with low dose methotrexate in Japanese patients with rheumatoid arthritis;Abe;Journal of Rheumatology,2006

2. Subcutaneous abatacept versus intravenous abatacept: A phase IIIb noninferiority study in patients with an inadequate response to methotrexate;Genovese;Arthritis and Rheumatism,2011

3. Adding tocilizumab or switching to tocilizumab monotherapy in methotrexate inadequate responders: 24-week symptomatic and structural results of a 2-year randomised controlled strategy trial in rheumatoid arthritis (ACT-RAY);Dougados;Annals of the rheumatic diseases,2013

4. Clinical efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis and poor prognostic factors;Westhovens;Annals of the Rheumatic Diseases,2009

5. Ahmed S Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis Internal Medicine Journal 2010 20

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