1. Heart of England NHS Foundation Trust, Birmingham Heartlands Hospital; Academic Department of Anaesthesia, Critical Care, Pain and Resuscitation; 1/F MIDRU Building, Birmingham Heartlands Hospital, Bordersley Green East Birmingham UK B9 5SS
2. University of Birmingham; School of Clinical and Experimental Medicine, College of Medical and Dental Sciences; Birmingham UK
3. Division of Health Sciences, Warwick Medical School, The University of Warwick; Warwick Clinical Trials Unit; Gibbet Hill Road Coventry UK CV4 7AL
4. University of Birmingham; Institute of Inflammation and Ageing; Queen Elizabeth Hospital Birmingham Edgbaston, Birmingham UK B15 2TT
5. The University of Sheffield; School of Health and Related Research; Sheffield UK
6. College of Medical and Dental Sciences, University of Birmingham; School of Clinical and Experimental Medicine; Birmingham UK