Deferasirox for managing iron overload in people with thalassaemia

Author:

Bollig Claudia1,Schell Lisa K2,Rücker Gerta3,Allert Roman4,Motschall Edith5,Niemeyer Charlotte M6,Bassler Dirk7,Meerpohl Joerg J1

Affiliation:

1. Medical Center - Univ. of Freiburg, Faculty of Medicine, Univ. of Freiburg; Cochrane Germany; Breisacher Straße 153 Freiburg Germany 79110

2. Cologne Germany

3. Faculty of Medicine and Medical Center - University of Freiburg; Institute for Medical Biometry and Statistics; Stefan-Meier-Str. 26 Freiburg Germany 79104

4. University Hospital Frankfurt, Goethe University; Department of Obstetrics and Gynaecology; Frankfurt Germany

5. Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg; Center for Medical Biometry and Medical Informatics; Stefan-Meier-Str. 26 Freiburg Germany 79104

6. University Medical Center Freiburg; Pediatric Hematology & Oncology, Center for Pediatrics & Adolescent Medicine; Mathildenstrasse 1 Freiburg Germany 79106

7. University Hospital Zurich and University of Zurich; Department of Neonatology; Frauenklinikstrasse 10 Zurich Switzerland

Publisher

Wiley

Subject

Pharmacology (medical)

Reference219 articles.

1. Iron chelation therapy with deferasirox (Exjade (R), ICL670) or deferoxamine is effective in reducing iron overload in patients with advanced fibrosis and cirrhosis;Angelucci;Blood,2005

2. Growth and development of paediatric patients with beta-thalassaemia treated with deferasirox for up to 5 years;Aydinok;Haematologica,2010

3. A comparison of novel serum markers for the assessment of liver fibrosis in patients with beta thalassemia major treated with deferasirox;Aydinok;Haematologica,2010

4. Iron chelation therapy with deferasirox (Exjade®, ICL670) or deferoxamine results in reduced hepatocellular inflammation and improved liver function in patients with transfusion-dependent anemia;Brissot;Blood,2005

5. Phase III evaluation of once-daily, oral therapy with ICL670 (Exjade (R)) versus deferoxamine in patients with beta-thalassemia and transfusional hemosiderosis;Cappellini;Blood,2004

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