Interleukin-6 blocking agents for treating COVID-19: a living systematic review

Author:

Ghosn Lina123,Chaimani Anna3,Evrenoglou Theodoros3,Davidson Mauricia123,Graña Carolina123,Schmucker Christine45,Bollig Claudia45,Henschke Nicholas6,Sguassero Yanina6,Nejstgaard Camilla Hansen78,Menon Sonia123,Nguyen Thu Van3,Ferrand Gabriel123,Kapp Philipp123,Riveros Carolina123,Ávila Camila9,Devane Declan1011,Meerpohl Joerg J45,Rada Gabriel912,Hróbjartsson Asbjørn78,Grasselli Giacomo131415,Tovey David1,Ravaud Philippe123,Boutron Isabelle123

Affiliation:

1. Cochrane France; Paris France

2. Centre d'Épidémiologie Clinique, AP-HP (Assistance Publique des Hôpitaux de Paris), Hôpital Hôtel Dieu; Paris France

3. Université de Paris, Centre of Research in Epidemiology and Statistics (CRESS), INSERM, F-75004; Paris France

4. Cochrane Germany; Cochrane Germany Foundation; Freiburg Germany

5. Institute for Evidence in Medicine (for Cochrane Germany Foundation); Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg; Freiburg Germany

6. Cochrane Response; Cochrane; London UK

7. Centre for Evidence-Based Medicine Odense (CEBMO) and Cochrane Denmark; Department of Clinical Research, University of Southern Denmark; Odense Denmark

8. Open Patient data Explorative Network (OPEN); Odense University Hospital; Odense Denmark

9. Epistemonikos Foundation; Santiago Chile

10. HRB-Trials Methodology Research Network; National University of Ireland Galway; Galway Ireland

11. Evidence Synthesis Ireland and Cochrane Ireland; Galway Ireland

12. UC Evidence Center, Cochrane Chile Associated Center; Pontificia Universidad Católica de Chile; Santiago Chile

13. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico; University of Milan; Milan Italy

14. Department of Anesthesia, Intensive Care and Emergency; Ospedale Maggiore Policlinico, University of Milan; Milan Italy

15. Department of Pathophysiology and Transplantation; Ospedale Maggiore Policlinico, University of Milan; Milan Italy

Publisher

Wiley

Subject

Pharmacology (medical)

Reference148 articles.

1. Interleukin-6 receptor antagonists in critically Ill patients with Covid-19;Gordon;New England Journal of Medicine,2021

2. Gordon AC Mouncey PR Al-Beidh F Rowan KM Nichol AD Arabi YM The REMAP-CAP Investigators Interleukin-6 receptor antagonists in critically ill patients with Covid-19 - preliminary report medRxiv [Preprint] 2021 10.1101/2021.01.07.21249390

3. Randomized, embedded, multifactorial adaptive platform trial for community- acquired pneumonia (REMAP-CAP) clinicaltrials.gov/ct2/show/NCT02735707 10.1101/2021.01.07.21249390

4. Effect of tocilizumab vs usual care in adults hospitalized with COVID-19 and moderate or severe pneumonia. A randomized clinical trial;Hermine;JAMA Internal Medicine,2021

5. CORIMUNO-19 - tocilizumab trial - TOCI (CORIMUNO-TOCI) (CORIMUNO-TOC) clinicaltrials.gov/ct2/show/NCT04331808

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