Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee surgery: a systematic review and network meta-analysis

Author:

Gibbs Victoria N1,Champaneria Rita12,Sandercock Josie12,Welton Nicky J3,Geneen Louise J12,Brunskill Susan J12,Dorée Carolyn12,Kimber Catherine12,Palmer Antony JR4,Estcourt Lise J5

Affiliation:

1. Systematic Review Initiative; NHS Blood and Transplant; Oxford UK

2. Nuffield Department of Clinical Laboratory Sciences; University of Oxford; Oxford UK

3. Bristol Medical School; University of Bristol; Bristol UK

4. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences; University of Oxford; Oxford UK

5. Haematology/Transfusion Medicine; NHS Blood and Transplant; Oxford UK

Publisher

Wiley

Reference700 articles.

1. Tranexamic acid reduces blood transfusion in total knee arthroplasty even when a blood conservation program is applied;Alvarez;Transfusion,2008

2. Clinical trial on the effect of tranexamic acid on bleeding and fibrinolysis in primary hip and knee replacement;Alvarez;Revista Espanola De Anestesiologia Y Reanimacion,2019

3. Clinical trial on the effect of tranexamic acid on bleeding and fibrinolysis in primary hip and knee replacement;Alvarez;Revista Espanola De Anestesiologia Y Reanimacion,2019

4. Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: A prospective, randomised, double-blind study of 86 patients;Benoni;Journal of Bone and Joint Surgery,1996

5. Tranexamic acid, given at the end of the operation, does not reduce postoperative blood loss in hip arthroplasty;Benoni;Acta Orthopaedica Scandinavica,2000

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