Mass balance and pharmacokinetics of an oral dose of 14 C‐napabucasin in healthy adult male subjects-Reference-Cited by-同舟云学术

Mass balance and pharmacokinetics of an oral dose of 14 C‐napabucasin in healthy adult male subjects

Published:2021-02 Issue:1 Volume:9 Page:
ISSN:2052-1707
Container-title:Pharmacology Research & Perspectives
language:en
Short-container-title:Pharmacol. Res. Perspect.

Author:

Dai Xiaoshu¹,Karol Michael D.¹,Hitron Matthew¹,Hard Marjie L.²,Blanchard John Evan³,Eraut Nicola C. J. E.⁴,Rich Natalie³,Gufford Brandon T.³

Affiliation:

1. Sumitomo Dainippon Pharma Oncology, Inc. Cambridge MA USA

2. Nuventra Inc. Durham NC USA

3. Covance, Inc. Madison WI USA

4. Covance Clinical Research Unit Ltd. Leeds UK

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/prp2.722

Reference23 articles.

1. Sumitomo Dainippon Pharma Oncology Inc.Sumitomo Dainippon Pharma Oncology Pipeline.https://www.sdponcology.com/pipeline/. Accessed October 21 2020.

2. Evaluation of Tumor Cell–Tumor Microenvironment Component Interactions as Potential Predictors of Patient Response to Napabucasin

3. Bioactivation of Napabucasin Triggers Reactive Oxygen Species–Mediated Cancer Cell Death

4. A Phase Ib/II Study of Cancer Stemness Inhibitor Napabucasin (BB608) Combined with Weekly Paclitaxel in Advanced Triple Negative Breast Cancer.

5. A phase 1b/2 study of napabucasin with weekly paclitaxel in advanced, previously treated platinum resistant ovarian cancer.

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