Clinical Characteristics of Moxifloxacin‐Related Arrhythmias and Development of a Predictive Nomogram: A Case Control Study

Author:

Li Peng12ORCID,Zhu Man1,Gao Ao1,Guo Haili12,Fu An12,Zhao Anqi12,Guo Daihong1ORCID

Affiliation:

1. Department of Pharmacy Medical Supplies Center Chinese People's Liberation Army General Hospital Beijing China

2. Chinese People's Liberation Army Medical School Beijing China

Abstract

AbstractThis study aimed to analyze the incidence, clinical characteristics, and risk factors of moxifloxacin‐related arrhythmias and electrocardiographic alterations in hospitalized patients using real‐world data. Concurrently, a nomogram was established and validated to provide a practical tool for prediction. Retrospective automatic monitoring of inpatients using moxifloxacin was performed in a Chinese hospital from January 1, 2017, to December 31, 2021, to obtain the incidence of drug‐induced arrhythmias and electrocardiographic alterations. Propensity score matching was conducted to balance confounders and analyze clinical characteristics. Based on the risk and protective factors identified through logistic regression analysis, a prediction nomogram was developed and internally validated using the Bootstrap method. Arrhythmias and electrocardiographic alterations occurred in 265 of 21,711 cases taking moxifloxacin, with an incidence of 1.2%. Independent risk factors included medication duration (odds ratio [OR] 1.211, 95% confidence interval [CI] 1.156–1.270), concomitant use of meropenem (OR 4.977, 95% CI 2.568–9.644), aspartate aminotransferase >40 U/L (OR 3.728, 95% CI 1.800–7.721), glucose >6.1 mmol/L (OR 2.377, 95% CI 1.531–3.690), and abnormally elevated level of amino‐terminal brain natriuretic peptide precursor (OR 2.908, 95% CI 1.640–5.156). Concomitant use of cardioprotective drugs (OR 0.430, 95% CI 0.220–0.841) was a protective factor. The nomogram showed good differentiation and calibration, with enhanced clinical benefit. The incidence of moxifloxacin‐related arrhythmias and electrocardiographic alterations is in the range of common. The nomogram proves valuable in predicting the risk in the moxifloxacin‐administered population, offering significant clinical applications.

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3