Detecting drug resistance in pancreatic cancer organoids guides optimized chemotherapy treatment

Author:

Hennig Alexander12345ORCID,Baenke Franziska1ORCID,Klimova Anna23456,Drukewitz Stephan23457,Jahnke Beatrix1,Brückmann Sascha8,Secci Ramona910,Winter Christof91011,Schmäche Tim12345,Seidlitz Therese1,Bereuter Jean‐Paul1,Polster Heike1,Eckhardt Lisa7,Schneider Sidney A1,Brückner Stefan12,Schmelz Renate12,Babatz Jana12,Kahlert Christoph12345,Distler Marius12345,Hampe Jochen1213,Reichert Maximilian111415,Zeißig Sebastian1213,Folprecht Gunnar12,Weitz Jürgen12345,Aust Daniela8,Welsch Thilo1,Stange Daniel E12345

Affiliation:

1. Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus Technische Universität Dresden Dresden Germany

2. National Center for Tumor Diseases (NCT) Dresden Germany

3. German Cancer Research Center (DKFZ) Heidelberg Germany

4. Faculty of Medicine and University Hospital Carl Gustav Carus Technische Universität Dresden Dresden Germany

5. Helmholtz‐Zentrum Dresden – Rossendorf (HZDR) Dresden Germany

6. Institute for Medical Informatics and Biometry Technical University Dresden Dresden Germany

7. Core Unit for Molecular Tumor Diagnostics (CMTD) Technical University Dresden Dresden Germany

8. Institute of Pathology and Tumor‐ and Normal Tissue Bank of the University Cancer Center (UCC), University Hospital Carl Gustav Carus, Medical Faculty Technische Universität Dresden Dresden Germany

9. Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine Technical University of Munich Munich Germany

10. TranslaTUM, Center for Translational Cancer Research Technical University of Munich Munich Germany

11. German Cancer Consortium (DKTK), Partner Site Munich, and German Cancer Research Center (DKFZ) Heidelberg Germany

12. Department of Medicine I University Hospital Carl Gustav Carus Dresden Germany

13. Center for Regenerative Therapies (CRTD) Technische Universität (TU) Dresden Dresden Germany

14. Translational Pancreatic Cancer Research Center, Medical Clinic and Polyclinic II, Klinikum rechts der Isar Technical University of Munich Munich Germany

15. Center for Protein Assemblies (CPA) Technische Universität München Munich Germany

Funder

Deutsche Forschungsgemeinschaft

Deutsche Krebshilfe

Publisher

Wiley

Subject

Pathology and Forensic Medicine

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