Genome‐wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways

Author:

Sherva Richard1,Gross Alden2,Mukherjee Shubhabrata3,Koesterer Ryan4,Amouyel Philippe567,Bellenguez Celine567,Dufouil Carole8,Bennett David A.910,Chibnik Lori1112,Cruchaga Carlos13141516,del‐Aguila Jorge13141516,Farrer Lindsay A.117181920,Mayeux Richard212223,Munsie Leanne24,Winslow Ashley25,Newhouse Stephen2627282930,Saykin Andrew J.31,Kauwe John S.K.32,Crane Paul K.3,Green Robert C.33343536,

Affiliation:

1. Department of Medicine (Biomedical Genetics) Boston University School of Medicine Boston Massachusetts USA

2. Johns Hopkins Bloomberg School of Public Health Johns Hopkins Center on Aging and Health Baltimore Maryland USA

3. Department of Medicine University of Washington Seattle Washington USA

4. Programs in Metabolism and Medical & Population Genetics Broad Institute Cambridge Massachusetts USA

5. Inserm CHU Lille Institute Pasteur de Lille U1167 ‐ RID‐AGE ‐ Risk factors and molecular determinants of age‐related diseases; Institute Pasteur de Lille University of Lille Lille Cedex France

6. Institut Pasteur de Lille Lille France

7. DISTALZ Laboratory of Excellence (LabEx) University of Lille Lille France

8. Inserm Unit 1219 Bordeaux Population Health CIC 1401‐EC (Clinical Epidemiology) University of Bordeaux ISPED (Bordeaux School of Public Health) Bordeaux University Hospital Bordeaux France

9. Rush Alzheimer's Disease Center Rush University Medical Center Chicago Illinois USA

10. Department of Neurological Sciences Rush University Medical Center Chicago Illinois USA

11. Department of Epidemiology Harvard T.H. Chan School of Public Health Boston Massachusetts USA

12. Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge Massachusetts USA

13. Hope Center for Neurological Disorders Washington University School of Medicine St. Louis Missouri USA

14. Department of Psychiatry Washington University School of Medicine St. Louis Missouri USA

15. Knight Alzheimer's Disease Research Center Washington University School of Medicine St. Louis Missouri USA

16. NeuroGenomics and Informatics Washington University School of Medicine Saint Louis USA

17. Bioinformatics Graduate Program Boston University Boston Massachusetts USA

18. Department of Neurology Boston University School of Medicine Boston Massachusetts USA

19. Department of Biostatistics Boston University School of Public Health Boston Massachusetts USA

20. Department of Ophthalmology Boston University School of Medicine Boston Massachusetts USA

21. Taub Institute for Research on Alzheimer's Disease and the Aging Brain Vagelos College of Physicians and Surgeons Columbia University New York New York USA

22. The Gertrude H. Sergievsky Center College of Physicians and Surgeons Columbia University New York New York USA

23. Department of Neurology College of Physicians and Surgeons New York‐Presbyterian Hospital Columbia University Medical Center New York New York USA

24. Eli Lilly and Company Lilly Corporate Center Indianapolis Indiana USA

25. Orphan Disease Center Perelman School of Medicine University of Pennsylvania Pennsylvania Pennsylvania USA

26. Department of Biostatistics and Health Informatics King's College London Institute of Psychiatry, Psychology and Neuroscience London UK

27. NIHR BioResource Centre Maudsley Psychology and Neuroscience (IoPPN) King's College London NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry London UK

28. Health Data Research UK London University College London London UK

29. Institute of Health Informatics University College London London UK

30. The National Institute for Health Research University College London Hospitals Biomedical Research Centre University College London London UK

31. Indiana Alzheimer Disease Center and Department of Radiology and Imaging Sciences IU Health Neuroscience Center Indiana University School of Medicine Indianapolis Indiana USA

32. Department of Biology Brigham Young University Provo Utah USA

33. Division of Genetics Department of Medicine Brigham and Women's Hospital Boston Massachusetts USA

34. The Broad Institute of MIT and Harvard Cambridge Massachusetts USA

35. Harvard Medical School Boston Massachusetts USA

36. Partners HealthCare Personalized Medicine Boston Massachusetts USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Clinical Neurology,Developmental Neuroscience,Health Policy,Epidemiology

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