Neuroimaging correlates of Alzheimer's disease biomarker concentrations in a racially diverse high‐risk cohort of middle‐aged adults

Author:

Misiura Maria12,Munkombwe Chinkuli3,Igwe Kay4,Verble Danielle D.5,Likos Kelly D. S.5,Minto Lex1,Bartlett Alexandria1,Zetterberg Henrik678910,Turner Jessica A.11,Dotson Vonetta M.112,Brickman Adam M.413,Hu William T.14,Wharton Whitney5

Affiliation:

1. Department of Psychology Georgia State University Atlanta Georgia USA

2. Tri‐Institutional Center for Translational Research in Neuroimaging & Data Science, Georgia State University, Georgia Institute of Technology Emory University Atlanta Georgia USA

3. Neuroscience Institute Georgia State University Atlanta Georgia USA

4. Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center, and Department of Neurology, Vagelos College of Physicians and Surgeons Columbia University New York New York USA

5. Nell Hodgson Woodruff School of Nursing Emory University Atlanta Georgia USA

6. The Sahlgrenska Academy, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Mölndal and Gothenburg University of Gothenburg Gothenburg Sweden

7. Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden

8. Department of Neurodegenerative Disease, UCL Institute of Neurology UCL Queen Square Institute of Neurology London UK

9. UK Dementia Research Institute at UCL, Maple House London UK

10. Hong Kong Center for Neurodegenerative Diseases Hong Kong China

11. Department of Psychiatry and Mental Health, College of Medicine Ohio State University Columbus Ohio USA

12. Gerontology Department Georgia State University Atlanta Georgia USA

13. Department of Neurology, Vagelos College of Physicians and Surgeons Columbia University New York New York USA

14. Institute for Health, Health Care Policy, and Aging Research Rutgers University New Brunswick New Jersey USA

Abstract

AbstractINTRODUCTIONIn this study, we investigated biomarkers in a midlife, racially diverse, at‐risk cohort to facilitate early identification and intervention. We examined neuroimaging measures, including resting state functional magnetic resonance imaging (fMRI), white matter hyperintensity vo (WMH), and hippocampal volumes, alongside cerebrospinal fluid (CSF) markers.METHODSOur data set included 76 cognitively unimpaired, middle‐aged, Black Americans (N = 29, F/M = 17/12) and Non‐Hispanic White (N = 47, F/M = 27/20) individuals. We compared cerebrospinal fluid phosphorylated tau141 and amyloid beta (Aβ)42 to fMRI default mode network (DMN) subnetwork connectivity, WMH volumes, and hippocampal volumes.RESULTSResults revealed a significant race × Aβ42 interaction in Black Americans: lower Aβ42 was associated with reduced DMN connectivity and increased WMH volumes regions but not in non‐Hispanic White individuals.DISCUSSIONOur findings suggest that precuneus DMN connectivity and temporal WMHs may be linked to Alzheimer's disease risk pathology during middle age, particularly in Black Americans.Highlights Cerebrospinal fluid (CSF) amyloid beta (Aβ)42 relates to precuneus functional connectivity in Black, but not White, Americans. Higher white matter hyperintensity volume relates to lower CSF Aβ42 in Black Americans. Precuneus may be a hub for early Alzheimer's disease pathology changes detected by functional connectivity.

Funder

National Institute on Aging

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3