Synthesis of a deuterated 6-AmHap internal standard for the determination of hapten density in a heroin vaccine drug product

Author:

Makarova Mariia1,Barrientos Rodell C.23,Torres Oscar B.23,Matyas Gary R.2,Jacobson Arthur E.1,Sulima Agnieszka1ORCID,Rice Kenner C.1

Affiliation:

1. Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health; Department of Health and Human Services; Bethesda Maryland USA

2. Laboratory of Adjuvant and Antigen Research, U.S. Military HIV Research Program; Walter Reed Army Institute of Research; Silver Spring Maryland USA

3. U.S. Military HIV Research Program; Henry M. Jackson Foundation for the Advancement of Military Medicine; Bethesda Maryland USA

Funder

Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Army Medical Research and Materiel Command

National Institutes of Health

NIH Intramural Research Program (IRP) of the National Institute on Drug Abuse and the National Institute of Alcohol Abuse and Alcoholism

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Radiology Nuclear Medicine and imaging,Biochemistry,Analytical Chemistry

Reference20 articles.

1. Drug and opioid-involved overdose deaths-United States, 2017-2018;Wilson;MMWR,2020

2. NIDA The science of drug use and addiction: the basics 2020 1 30 www.Drugabuse.Gov/publications/media-guide/science-drug-use-addiction-basics

3. A comparative study of factors associated with relapse in alcohol dependence and opioid dependence;Kadam;Indian J Psychol Med,2017

4. Extended-release naltrexone to prevent opioid relapse in criminal justice offenders;Lee;N Engl J Med,2016

5. Changes in heroin self-administration by a rhesus monkey after morphine immunisation;Bonese;Nature,1974

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