Brain artery diameters and risk of dementia and stroke-Reference-Cited by-同舟云学术

Brain artery diameters and risk of dementia and stroke

Published:2024-02-08 Issue:4 Volume:20 Page:2497-2507
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Melgarejo Jesus D.¹²³^ORCID,Gurel Kursat⁴,Compton Cassidy Rose⁴,Liu Minghua⁴,Guzman Vanessa⁴,Assuras Stephanie⁴,Levin Bonnie E.⁵,Elkind Mitchell S. V.⁴⁶,Ikram M. Kamran¹⁷,Kavousi Maryam¹,Ikram M. Arfan¹,Wright Clinton⁸,Crivello Fabrice⁹,Laurent Alexandre⁹,Tzourio Christophe¹⁰,Vernooij Meike W.¹¹¹,Rundek Tatjana¹²,Zhang Zhen‐Yu²,Bos Daniel¹²¹¹,Gutierrez Jose⁴

Affiliation:

1. Department of Epidemiology Erasmus MC University Medical Center Rotterdam the Netherlands

2. Studies Coordinating Centre Research Unit Hypertension and Cardiovascular Epidemiology KU Leuven Department of Cardiovascular Sciences University of Leuven Leuven Belgium

3. Institute of Neuroscience University of Texas Rio Grande Valley Harlingen Texas USA

4. Department of Neurology Vagelos College of Physicians and Surgeons Columbia University New York New York USA

5. Department of Neurology Miller School of Medicine University of Miami Miami Florida USA

6. Department of Epidemiology Mailman School of Public Health Columbia University New York New York USA

7. Department of Neurology Erasmus MC University Medical Center Rotterdam the Netherlands

8. National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda Maryland USA

9. Institute of Neurodegenerative Diseases UMR5293, Neurofunctional Imaging Group Bordeaux France

10. Bordeaux Population Health Research Center Inserm, University Bordeaux Bordeaux France

11. Department of Radiology and Nuclear Medicine Erasmus MC University Medical Center Rotterdam the Netherlands

12. Department of Public Health Sciences and Evelyn F. McKnight Brain Institute Miller School of Medicine University of Miami Miami Florida USA

Abstract

AbstractINTRODUCTIONWe tested the association of brain artery diameters with dementia and stroke risk in three distinct population‐based studies using conventional T2‐weighted brain magnetic resonance imaging (MRI) images.METHODSWe included 8420 adults > 40 years old from three longitudinal population‐based studies with brain MRI scans. We estimated and meta‐analyzed the hazard ratios (HRs) of the brain and carotids and basilar diameters associated with dementia and stroke.RESULTOverall and carotid artery diameters > 95th percentile increased the risk for dementia by 1.74 (95% confidence interval [CI], 1.13–2.68) and 1.48 (95% CI, 1.12–1.96) fold, respectively. For stroke, meta‐analyses yielded HRs of 1.59 (95% CI, 1.04–2.42) for overall arteries and 2.11 (95% CI, 1.45–3.08) for basilar artery diameters > 95th percentile.DISCUSSIONIndividuals with dilated brain arteries are at higher risk for dementia and stroke, across distinct populations. Our findings underline the potential value of T2‐weighted brain MRI‐based brain diameter assessment in estimating the risk of dementia and stroke.

Funder

National Science Foundation

Fondation pour la Recherche Médicale

Mutuelle Générale de l'Education Nationale

Fondation de France

Publisher

Wiley

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