Synthesis and characterization of a deuterium labeled stercobilin: A potential biomarker for autism

Author:

Coffey Jordan M.1,Vadas Andrew J.2,Puleo Thomas R.3,Lewis Katelyn P.4,Pirrone Gregory F.5,Rudolph Heather L.6,Helms Eric D.1ORCID,Wood Troy D.7ORCID,Flynn-Charlebois Amber1ORCID

Affiliation:

1. Department of Chemistry; State University of New York at Geneseo; Geneseo New York USA

2. Department of Biology; State University of New York at Geneseo; Geneseo New York USA

3. Department of Chemistry; Colorado State University; Fort Collins Colorado USA

4. Fairleigh Dickinson University; School of Pharmacy & Health Sciences; Florham Park New Jersey USA

5. Process Research and Development; MRL, Merck & Co., Inc.; Rahway New Jersey USA

6. Thermo Fisher Scientific; Grand Island New York USA

7. University at Buffalo; Department of Chemistry; Buffalo New York USA

Funder

Geneseo Foundation

National Institutes of Health

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Radiology, Nuclear Medicine and imaging,Biochemistry,Analytical Chemistry

Reference16 articles.

1. The mechanism of heme oxygenase;Ortiz de Montellano;Curr Opin Chem Biol,2000

2. Turning green to gold;McDonagh;Nat Struct Biol,2001

3. Heme oxygenase-1 is expressed in carotid atherosclerotic plaques infected by Helicobacter pylori and is more prevalent in asymptomatic subjects;Ameriso;Stroke,2005

4. NSTA News http://www.nsta.org/publications/news/story.aspx?id=48991 2017

5. US Department of Health and Human services Autism https://catalog.ninds.nih.gov/pubstatic/09-1877/09-1877.pdf

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1. Cav1.2 channelopathies causing autism: new hallmarks on Timothy syndrome;Pflügers Archiv - European Journal of Physiology;2020-07

2. Stercobilin: A Putative Link between Autism and Gastrointestinal Distress?;Autism Spectrum Disorders - Advances at the End of the Second Decade of the 21st Century;2019-10-09

3. Examination of the Fragmentation Behavior of Hemin and Bilin Tetrapyrroles by Electrospray Ionization and Collision-induced Dissociation;MASS SPECTROM LETT;2018

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