Real‐world evidence for oncological outcomes after radiotherapy or surgery for <scp>T1a‐T1b</scp> glottic squamous cell carcinoma: A population‐based cohort study-Reference-Cited by-同舟云学术

Real‐world evidence for oncological outcomes after radiotherapy or surgery for T1a‐T1b glottic squamous cell carcinoma: A population‐based cohort study

Published:2023-08-09 Issue:10 Volume:45 Page:2505-2514
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Viani Gustavo Arruda¹²^ORCID,Moraes Fabio Ynoe²³,Marta Gustavo Nader²⁴,Kowalski Luiz Paulo⁵⁶,Gouveia Andre Guimaraes²⁷^ORCID

Affiliation:

1. Department of Medical Imagings, Hematology and Oncology, Ribeirão Preto Medical School University of São Paulo (FMRP‐USP) Ribeirão Preto Brazil

2. Latin America Cooperative Oncology Group (LACOG) Porto Alegre Brazil

3. Division of Radiation Oncology, Department of Oncology, Kingston General Hospital Queen's University Kingston Ontario Canada

4. Department of Radiation Oncology Hospital Sirio Libanês São Paulo Brazil

5. Department of Head and Neck Surgery and Otorhinolaryngology AC Camargo Cancer Center (ACCCC) Sao Paulo Brazil

6. Department of Head and Neck Surgery, São Paulo State Cancer Institute (ICESP), School of Medicine University of São Paulo (USP) São Paulo Brazil

7. Department of Radiation Oncology Americas Centro de Oncologia Integrado Rio de Janeiro Brazil

Abstract

AbstractBackgroundCompare outcomes after surgery (S) or radiotherapy (RT) for T1a‐T1b glottic squamous cell carcinoma (T1GSCC) in a population‐based cohort study.MethodsPatients diagnosed with T1GSCC from 1999 to 2020 were identified from a public database. Clinical, demographic, and social data were extracted. Treatment and patient groups and subgroups were compared with log‐rank test, Cox proportional test, and propensity‐score matched (PSM).ResultsEight hundred and eighty‐eight patients with T1GSCC were included in the study, with a median follow‐up of 61 months. The 5‐ and 10‐year overall survival (OS) S versus RT were 76% versus 71% and 60% versus 52% (p = 0.02), respectively. In the subgroup analysis, S was associated with better OS for T1b, male, and public service patients (p < 0.05). In the PSM cohort of S versus RT with 110 patients each, there was no significant difference in the OS, CSS, and LC.ConclusionsT1GSCC has favorable outcomes with S or RT.

Publisher

Wiley

Subject

Otorhinolaryngology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27470

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