CRISPR‐Cas9 –Mediated Genome Editing Confirms EPDR1 as an Effector Gene at the BMD GWAS ‐Implicated ‘ STARD3NL ’ Locus-Reference-Cited by-同舟云学术

CRISPR‐Cas9 –Mediated Genome Editing Confirms EPDR1 as an Effector Gene at the BMD GWAS ‐Implicated ‘ STARD3NL ’ Locus

Published:2021-07-23 Issue:9 Volume:5 Page:
ISSN:2473-4039
Container-title:JBMR Plus
language:en
Short-container-title:JBMR Plus

Author:

Pippin James A¹^ORCID,Chesi Alessandra¹^ORCID,Wagley Yadav²,Su Chun¹,Pahl Matthew C¹,Hodge Kenyaita M³,Johnson Matthew E¹,Wells Andrew D¹⁴^ORCID,Hankenson Kurt D²^ORCID,Grant Struan F A¹⁵⁶^ORCID

Affiliation:

1. Center for Spatial and Functional Genomics Children's Hospital of Philadelphia Philadelphia PA USA

2. Department of Orthopedic Surgery University of Michigan Medical School Ann Arbor MI USA

3. Genetics and Molecular Biology Graduate Program, Laney Graduate School Emory University Atlanta GA USA

4. Department of Pathology and Laboratory Medicine University of Pennsylvania Perelman School of Medicine Philadelphia PA USA

5. Department of Pediatrics University of Pennsylvania Perelman School of Medicine Philadelphia PA USA

6. Divisions of Genetics and Endocrinology Children's Hospital of Philadelphia Philadelphia PA USA

Funder

National Human Genome Research Institute

National Institute of Arthritis and Musculoskeletal and Skin Diseases

National Institute of Child Health and Human Development

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbm4.10531

Reference28 articles.

1. An atlas of genetic influences on osteoporosis in humans and mice

2. Genetics of osteoporosis from genome-wide association studies: advances and challenges

3. Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis

4. A Genomewide Association Study Identifies Two Sex-Specific Loci, at SPTB and IZUMO3 , Influencing Pediatric Bone Mineral Density at Multiple Skeletal Sites

5. A trans-ethnic genome-wide association study identifies gender-specific loci influencing pediatric aBMD and BMC at the distal radius

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