Development and validation of a UHPLC-MS/MS method for the simultaneous determination of five bioactive flavonoids in rat plasma and comparative pharmacokinetic study after oral administration of Xiaochaihu Tang and three compatibilities

Author:

Bo Yunhai1,Wang Lijuan1,Wu Xiao1,Zhao Longshan1,Yang Jingyu2,Xiong Zhili1,Wu Chunfu2

Affiliation:

1. School of Pharmacy; Shenyang Pharmaceutical University; Shenyang Liaoning Province P. R. China

2. Department of Pharmacology; Shenyang Pharmaceutical University; Shenyang Liaoning Province P. R. China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Filtration and Separation,Analytical Chemistry

Reference24 articles.

1. Chen , H. Shang Han Lun 1st ed Academy Press Beijing 2007 87

2. Xiaochaihutang prevents depressive-like behaviour in rodents by enhancing the serotonergic system;Su;J. Pharm. Pharmacol.,2014

3. Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress;Su;J. Ethnopharmacol.,2014

4. Clinical observation on 35 cases of Xiaochaihu Decoction in the treatment of depression;Chen;Zhejiang J. Tradit. Chin. Med.,2010

5. Current understanding on antihepatocarcinoma effects of xiao chai hu tang and its constituents;Zheng;Evid-based Compl. Alt. Med.,2013

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