High-throughput LC-MS/MS method with 96-well plate precipitation for the determination of arotinolol and amlodipine in a small volume of rat plasma: Application to a pharmacokinetic interaction study

Author:

Qian Zheyuan1,Le Jian2,Chen Xiujuan13,Li Shengni13,Song Hongjie4,Hong Zhanying1ORCID

Affiliation:

1. Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University; Shanghai Key Laboratory for Pharmaceutical Metabolites Research; Shanghai China

2. Shanghai Institute of Food and Drug Control; Shanghai China

3. Bioanalytical Service, WuXi AppTec Co., Ltd.; Waigaoqiao Free Trade Zone; Shanghai China

4. Department of Pharmacy, Changhai Hospital; Second Military Medical University; Shanghai China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Filtration and Separation,Analytical Chemistry

Reference22 articles.

1. Risk stratification in hypertension: new insights from the Framingham study;Kannel;Am. J. Hypertens.,2000

2. Managing hypertension using combination therapy;Frank;Am. Fam. Physician,2008

3. A comparative study of atenolol, nifedipine and their combination in the treatment of hypertension;Smith;S. Afr. Med. J.,1991

4. Clinical studies of benidipine hydrochloride combining metoprolol in senile hypertension;Feng;J. Clin. Psychosom. Dis.,2007

5. Clinical trial of arotinolol in the treatment of hypertension: dippers vs. non-dippers;Wu;Hypertens. Res.,2001

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