Liquid chromatography tandem mass spectrometry with triple stage fragmentation for highly selective analysis and pharmacokinetics of alarelin in rat plasma

Author:

Zhang Zhi12,Li Runzhi12,Liu Shihao3,Yin Lei14ORCID,Xu Tongtong5,Fawcett John Paul12,Gu Jingkai12ORCID

Affiliation:

1. College of Life ScienceJilin University Changchun P. R. China

2. Beijing Institute of Drug Metabolism Beijing P. R. China

3. Department of PharmacyShengjing Hospital of China Medical University Shenyang P. R. China

4. Research Institute of Translational MedicineThe First Bethune Hospital of Jilin University Changchun P. R. China

5. Changchun Center for Drug and Food Control Changchun P. R. China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Filtration and Separation,Analytical Chemistry

Reference15 articles.

1. Alarelin active immunization influences expression levels of GnRHR, FSHR and LHR proteins in the ovary and enhances follicular development in ewes

2. Comparison of alarelin and triptorelin in the long‐protocol ovulation induction in in vitro fertilization and embryo transfer;Duan J. L.;Zhonghua Nan Ke Xue,2010

3. Ovarian suppression with gonadotropin‐releasing hormone analogues (Gn‐RH) in high risk premenopausal breast cancer patients (PM‐HR‐BC): Decrease of T regulatory cells (T‐regs) and of vascular endothelial growth factor (VEGF);Recchia F.;Cancer Res

4. Expression of gonadotropin-releasing hormone receptor and effect of gonadotropin-releasing hormone analogue on proliferation of cultured gastric smooth muscle cells of rats

5. Electromembrane extraction of gonadotropin-releasing hormone agonists from plasma and wastewater samples

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