Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells

Author:

McGee-Lawrence Meghan E12,Carpio Lomeli R3,Schulze Ryan J4,Pierce Jessica L2,McNiven Mark A34,Farr Joshua N5,Khosla Sundeep5,Oursler Merry Jo35,Westendorf Jennifer J13

Affiliation:

1. Department of Orthopedic Surgery; Mayo Clinic; Rochester MN USA

2. Department of Cellular Biology and Anatomy; Georgia Regents University; Augusta GA USA

3. Department of Biochemistry and Molecular Biology; Mayo Clinic; Rochester MN USA

4. Department of Medicine, Division of Gastroenterology and Endocrinology; Mayo Clinic; Rochester MN USA

5. Department of Medicine, Division of Endocrinology; Mayo Clinic; Rochester MN USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

Reference88 articles.

1. Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis;Justesen;Biogerontology,2001

2. Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis;Verma;J Clin Pathol,2002

3. Comparison of the relationship between bone marrow adipose tissue and volumetric bone mineral density in children and adults;Shen;J Clin Densitom,2014

4. Potential value of vertebral proton MR spectroscopy in determining bone weakness;Schellinger;AJNR Am J Neuroradiol,2001

5. Mechanisms of disease: is osteoporosis the obesity of bone;Rosen;Nat Clin Pract Rheumatol,2006

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