Brief case report: A case of FOLFIRI—Induced psychosis

Abstract

Key points Psychosis may occur due to the FOLFIRI chemotherapy regimen. An exhaustive approach to confounding elements of a patient's medical history should be taken to rule out competing causes of psychosis. Both 5‐FU and Irinotecan may be implicated in psychosis, though which agent in particular is the cause is unclear. Risperidone assisted in resolution of this patient's psychosis whilst Olanzapine and Quetiapine did not. Both 5‐FU and Irinotecan have pharmacologic traits that may induce changes in mental status.