Transition Metal‐Catalyzed C−H Activation/Annulation Approaches to Isoindolo[2,1‐b]isoquinolin‐5(7H)‐ones

Author:

Tang Xiao1,Ding Songtao1,Song Liangliang2ORCID,Van der Eycken. Erik V.34

Affiliation:

1. College of Science Nanjing Forestry University Nanjing 210037 China

2. Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering Nanjing Forestry University Nanjing 210037, Jiangsu China

3. Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC) Department of Chemistry University of Leuven (KU Leuven) Celestijnenlaan 200F B-3001 Leuven Belgium

4. Peoples' Friendship University of Russia (RUDN University) Miklukho-Maklaya Street 6 117198 Moscow Russia

Abstract

AbstractThe isoindolo[2,1‐b]isoquinolin‐5(7H)‐one scaffold is widely present in lots of bioactive natural products. Diverse types of strategies have been developed to construct this scaffold. Recently, transition metal‐catalyzed C−H activation/annulation is emerging as a powerful and straightforward method to construct diverse polyheterocycles with high atom‐ and step‐economy. It also has been employed for the synthesis of the isoindolo[2,1‐b]isoquinolin‐5(7H)‐one scaffold. This review provides an introduction to recent advances for the preparation of isoindolo[2,1‐b]isoquinolin‐5(7H)‐ones by using transition metal‐catalyzed C−H activation/annulation. It will help researchers to find hidden opportunities and accelerate the discovery of novel transformations based on C−H activation/annulation.

Funder

Natural Science Foundation of Jiangsu Province

Natural Science Research of Jiangsu Higher Education Institutions of China

Publisher

Wiley

Subject

Materials Chemistry,General Chemical Engineering,Biochemistry,General Chemistry

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