Universal screening for Lynch syndrome in a large consecutive cohort of Chinese colorectal cancer patients: High prevalence and unique molecular features

Author:

Jiang Wu12ORCID,Cai Mu-Yan13,Li Shi-Yong4,Bei Jin-Xin15,Wang Fang16,Hampel Heather7,Ling Yi-Hong13,Frayling Ian M.89,Sinicrope Frank A.10,Rodriguez-Bigas Miguel A.11,Dignam James J.12,Kerr David J.13,Rosell Rafael14,Mao Mao4,Li Ji-Bin15,Guo Yun-Miao15,Wu Xiao-Yan16,Kong Ling-Heng12,Tang Jing-Hua12,Wu Xiao-Dan12,Li Chao-Feng16,Chen Jie-Rong15,Ou Qing-Jian125,Ye Ming-Zhi4,Guo Feng-Ming4,Han Peng4,Wang Qi-Wei17,Wan De-Sen12,Li Li18,Xu Rui-Hua119ORCID,Pan Zhi-Zhong12,Ding Pei-Rong12,

Affiliation:

1. Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine; Guangzhou China

2. Department of Colorectal Surgery; Sun Yat-sen University Cancer Center; Guangzhou People's Republic of China

3. Department of Pathology; Sun Yat-sen University Cancer Center; Guangzhou People's Republic of China

4. BGI-Guangzhou Medical Laboratory; BGI-Shenzhen People's Republic of China

5. Department of Experimental Research; Sun Yat-sen University Cancer Center; Guangzhou People's Republic of China

6. Department of Molecular Diagnostics; Sun Yat-sen University Cancer Center; Guangzhou People's Republic of China

7. Division of Human Genetics, Department of Internal Medicine; The Ohio State University Comprehensive Cancer Center; Columbus OH USA

8. Institute of Cancer and Genetics; Cardiff University; Cardiff United Kingdom

9. All-Wales Medical Genetics Service, Institute of Medical Genetics; University Hospital of Wales; Cardiff United Kingdom

10. Department of Oncology; Mayo Clinic; Rochester MN

11. Department of Surgical Oncology; The University of Texas MD Anderson Cancer Center; Houston TX

12. Department of Public Health Sciences; The University of Chicago Biological Sciences; Chicago IL

13. Department of Clinical Pharmacology, OCRB, Churchill Campus, Headington; University of Oxford; Oxford United Kingdom

14. Catalan Institute of Oncology; Germans Trias i Pujol Health Sciences Institute and Hospital; Badalona, Barcelona Spain

15. Department of Clinical Research; Sun Yat-sen University Cancer Center; Guangzhou People's Republic of China

16. Department of Information Technology; Sun Yat-sen University Cancer Center; Guangzhou People's Republic of China

17. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center; Sun Yat-sen University; Guangzhou People's Republic of China

18. Imaging Diagnosis and Interventional Center; Sun Yat-sen University Cancer Center; Guangzhou People's Republic of China

19. Department of Medical Oncology; Sun Yat-sen University Cancer Center; Guangzhou People's Republic of China

Funder

National Key R&D Program of China

Health & Medical collaborative innovation project of Guangzhou city

the Fundamental Research Funds for young teachers in basic research of Sun Yat-sen University

the Pearl River Nova Program of Guangzhou

the Science and Technology Project Foundation of Guangdong Province

the Science and Technology Project of Guangzhou

Publisher

Wiley

Subject

Cancer Research,Oncology

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