The ‘peptide for life’ initiative in the emergency department study

Author:

Bayes‐Genis Antoni1,Krljanac Gordana2,Zdravković Marija3,Ašanin Milika2,Stojšić‐Milosavljević Anastazija4,Radovanović Slavica5,Kovačević Tamara Preradović6,Selaković Aleksandar7,Milinković Ivan2,Polovina Marija2,Glavaš Duška8,Srbinovska Elizabeta910,Bulatović Nebojša11,Miličić Davor12,Čikeš Maja12,Babić Zdravko13,Šikić Jozica14,Kušljugić Zumreta15,Hudić Larisa Dizdarević15,Arfsten Henrike16,Meems Laura M.G.17,Metra Marco18,Rosano Giuseppe19,Seferović Petar M.20,

Affiliation:

1. Heart Institute Hospital Universitari Germans Trias i Pujol, CIBERCV Barcelona Spain

2. Cardiology Clinic, University Medical Center Medical Faculty University of Belgrade Belgrade Serbia

3. Medical Faculty University of Belgrade University Clinical Hospital Center Bezanijska kosa Belgrade Serbia

4. Cardiology Clinic, Institute for Cardiovascular Diseases of Vojvodina Medical Faculty University of Novi Sad Novi Sad Serbia

5. Department of Cardiology University Clinical Hospital Center ‘Dr Dragisa Misovic‐Dedinje’ Belgrade Serbia

6. Clinic for Cardiovascular Diseases, University Clinical Centre of the Republic of Srpska, Medical Faculty University of Banja Luka Banja Luka Bosnia and Herzegovina

7. Clinic for Internal Medicine General Hospital Užice Užice Serbia

8. Department of Cardiovascular Medicine, Clinical Hospital Center Split University of Split Faculty of Medicine Split Croatia

9. University Clinic of Cardiology Skopje Macedonia

10. Medical Faculty University ‘Ss Cyril and Methodius’ Skopje Macedonia

11. Cardiology Clinic, Clinical Center Podgorica School of Medicine University of Podgorica Podgorica Montenegro

12. University of Zagreb School of Medicine, Department of Cardiovascular Diseases University Hospital Center Zagreb Zagreb Croatia

13. Clinic for Cardiovascular diseases University Hospital Center Sestre milosrdnice Zagreb Croatia

14. Department for Cardiovascular Diseases, School of Medicine, Clinical Hospital Center Sveti Duh University of Zagreb Zagreb Croatia

15. Medical School and University Clinical Centre Tuzla Tuzla Bosnia and Herzegovina

16. Department of Internal Medicine II, Division of Cardiology Medical University of Vienna Vienna Austria

17. Department of Cardiology, University Medical Center Groningen University of Groningen Groningen Netherlands

18. Department of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, ASST Spedali Civili University of Brescia Brescia Italy

19. IRCCS San Raffaele Pisana Rome Italy

20. Medical Faculty University of Belgrade, Serbian Academy of Sciences and Arts University Medical Center Belgrade Serbia

Abstract

AbstractAimsNatriuretic peptide (NP) uptake varies in Emergency Departments (EDs) across Europe. The ‘Peptide for Life’ (P4L) initiative, led by Heart Failure Association, aims to enhance NP utilization for early diagnosis of heart failure (HF). We tested the hypothesis that implementing an educational campaign in Western Balkan countries would significantly increase NP adoption rates in the ED.Methods and resultsThis registry examined NP adoption before and after implementing the P4L‐ED study across 10 centres in five countries: Bosnia and Herzegovina, Croatia, Montenegro, North Macedonia, and Serbia. A train‐the‐trainer programme was implemented to enhance awareness of NP testing in the ED, and centres without access received point‐of‐care instruments. Differences in NP testing between the pre‐P4L‐ED and post‐P4L‐ED phases were evaluated. A total of 2519 patients were enrolled in the study: 1224 (48.6%) in the pre‐P4L‐ED phase and 1295 (51.4%) in the post‐P4L‐ED phase. NP testing was performed in the ED on 684 patients (55.9%) during the pre‐P4L‐ED phase and on 1039 patients (80.3%) during the post‐P4L‐ED phase, indicating a significant absolute difference of 24.4% (95% CI: 20.8% to 27.9%, P < 0.001). The use of both NPs and echocardiography significantly increased from 37.7% in the pre‐P4L‐ED phase to 61.3% in the post‐P4L‐ED phase. There was an increased prescription of diuretics and SGLT2 inhibitors during the post‐P4L‐ED phase.ConclusionsBy increasing awareness and providing resources, the utilization of NPs increased in the ED, leading to improved diagnostic accuracy and enhanced patient care.

Publisher

Wiley

Subject

Cardiology and Cardiovascular Medicine

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