Affiliation:
1. Chemistry Department, Faculty of Science Cairo University Giza Egypt
2. Common First Year Deanship Jouf University Sakaka Saudi Arabia
Abstract
AbstractIn this study, we aimed to establish an efficient method for synthesizing two new series of arene‐linked pyrazolo[1,5‐a]pyrimidines. This was achieved by reacting 1H‐pyrazole‐3,5‐diamines with the respective acetophenones and benzaldehydes in a 1:1:1 ratio. To optimize this three‐component reaction, various bases, and solvents were investigated. Use of two equivalents of KOH in ethanol at reflux for 4–6 h resulted in 89%–96% yields of the desired products. Structure of new products was elucidated by considering their elemental and spectral data.
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4 articles.
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