Application of capillary electrophoresis with capacitively contactless conductivity detection for biomedical analysis

Author:

Elbashir Abdalla A.12,Osman Abdelbagi3,Elawad Mohammed4,Ziyada Abobakr K.5,Aboul‐Enein Hassan Y.6ORCID

Affiliation:

1. Department of Chemistry College of Science King Faisal University Al‐Hofuf Al‐Ahsa Saudi Arabia

2. Department of Chemistry Faculty of Science University of Khartoum Khartoum Sudan

3. Department of Chemical Engineering College of Engineering Najran University Najran Saudi Arabia

4. Department of Chemistry Faculty of Science Omdurman Islamic University Omdurman Sudan

5. Department of General Studies Jubail Industrial College Jubail Industrial City Saudi Arabia

6. Pharmaceutical and Medicinal Chemistry Department Division of Pharmaceutical and Drug Industries Research Division National Research Centre Cairo Egypt

Abstract

AbstractThe coupling of capillary electrophoresis (CE) with capacitively coupled contactless conductivity detection (C4D) has become convenient analytical method for determination of small molecules that do not possess chromogenic or fluorogenic group. The implementations of CE with C4D in the determination of inorganic and organic ions and amino acids in biomedical field are demonstrated. Attention on background electrolyte composition, sample treatment procedures, and the utilize of multi‐detection systems are described. A number of tables summarizing highly developed CE‐C4D methods and the figures of merit attained are involved. Lastly, concluding remarks and perspectives are argued.

Publisher

Wiley

Subject

Clinical Biochemistry,Biochemistry,Analytical Chemistry

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